CRISPR Precision Studio is an open-source CRISPR guide design platform that discovers, ranks, explains, and validates guide RNAs in one lightweight application. It combines interpretable on-target scoring, both-strand off-target analysis, calibrated uncertainty, base-editing and prime-editing design, genome-wide search, multiplex library design, and per-feature explanations through a FastAPI-based local platform. Built to run entirely offline without GPUs, cloud services, or API keys, it provides transparent, reproducible CRISPR analysis for research workflow